translocations or amplifications in addition to the genomic alterations now current in the initial CLL, but lack the common mutations noticed in Principal DLBCL indicating which they may correspond to a different Organic classification.

This methylation profile is currently obtained at the MBL stage3 and stays rather stable after some time. Nevertheless, some CLL have intratumor variability in specified locations, which may alter the expression of many genes and aid tumor evolution.seventy one Of Observe, this variability is bigger in U-CLL than in M-CLL and is connected with raising number of subclones.7,71

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This methylation profile is now acquired within the MBL stage3 and remains rather stable eventually. Nonetheless, some CLL have intratumor variability in certain areas, which can change the expression of numerous genes and aid tumor evolution.71 Of Notice, this variability is bigger in U-CLL than in M-CLL and it is connected to growing amount of subclones.seven,71

り当て制御を行えば，性能向上が見込めると考えられる． 理論計算とシミュレーションによる評価結果から，提案

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